When we think of animals saving human lives, we at least think of a huge, hairy St. Bernard dog finding a lost climber in the high snowy mountains. We are unlikely to think of an inconspicuous gray stony horseshoe crab. On the other hand, these creatures, far older than the dinosaurs, save millions of lives each year at the cost of their blood.<img src="/uploads/horseshoe_crab_5d2f430e60.jpeg" alt="horseshoe crab.jpeg" srcset="/uploads/thumbnail_horseshoe_crab_5d2f430e60.jpeg 218w,/uploads/small_horseshoe_crab_5d2f430e60.jpeg 500w," sizes="100vw">@uwm.edu/Horseshoe Crab UpdateTheir light blue blood has the unique property of detecting and neutralizing toxic bacteria. Scientists have learned to use this amazing crab blood to make a safe vaccine. When the vaccine is manufactured, there could be dangerous bacteria left in it. If this happens, people who receive this vaccine risk serious consequences or even death.<img src="/uploads/a_group_of_horseshoe_crabs_2_2_2_2_2099327956.jpeg" alt="a-group-of-horseshoe-crabs-2-2-2-2.jpeg" srcset="/uploads/thumbnail_a_group_of_horseshoe_crabs_2_2_2_2_2099327956.jpeg 245w,/uploads/small_a_group_of_horseshoe_crabs_2_2_2_2_2099327956.jpeg 500w,/uploads/medium_a_group_of_horseshoe_crabs_2_2_2_2_2099327956.jpeg 750w,/uploads/large_a_group_of_horseshoe_crabs_2_2_2_2_2099327956.jpeg 1000w," sizes="100vw">@delawarepublic.org/How climate change and human activity are impacting horseshoe crabs amid annual countFor this reason, large numbers of horseshoe crabs are captured each year to serve as donors to save us all. After blood is taken, the horseshoe crabs are returned to the sea, but 30% to 50% still die. Dramatically, there are no fully effective horseshoe crab blood analogs to test the safety of the vaccine. Hence, scientists now face the critical challenge of maintaining populations of this unique creature.<img src="/uploads/Significant_changes_to_the_horseshoe_crab_bleeding_industry_may_protect_wildlife_ab113965cd.jpeg" alt="Significant changes to the horseshoe crab bleeding industry may protect wildlife .jpeg" srcset="/uploads/thumbnail_Significant_changes_to_the_horseshoe_crab_bleeding_industry_may_protect_wildlife_ab113965cd.jpeg 234w,/uploads/small_Significant_changes_to_the_horseshoe_crab_bleeding_industry_may_protect_wildlife_ab113965cd.jpeg 500w,/uploads/medium_Significant_changes_to_the_horseshoe_crab_bleeding_industry_may_protect_wildlife_ab113965cd.jpeg 750w,/uploads/large_Significant_changes_to_the_horseshoe_crab_bleeding_industry_may_protect_wildlife_ab113965cd.jpeg 1000w," sizes="100vw">@npr.org/Vaccines are still tested with horseshoe crab blood. The industry is finally changing

Significant changes to the horseshoe crab bleeding industry may protect wildlife .jpeg

What do we need to know about horseshoe crabs that have saved millions of human lives?

In the annals of human history, epidemics have cast dark shadows over civilizations, leaving behind trails of devastation and despair. While the world grapples with the ongoing COVID-19 pandemic, it's essential to acknowledge that humanity has faced even more formidable foes in the past. Here, we delve into five epidemics that surpassed the COVID-19 pandemic in their ferocity and impact.The Black Death: A Medieval ApocalypseThe Black Death, one of the most notorious pandemics in history, swept across Europe in the 14th century, leaving death and desolation in its wake. Originating in Asia, the bubonic plague spread rapidly along trade routes, carried by fleas infesting black rats. The sheer scale of death and devastation wrought by the Black Death is staggering, with estimates suggesting that it wiped out as much as 60% of Europe's population.<img src="/uploads/The_Black_Death_A_Medieval_Apocalypse_b7bde5c4f1.jpg" alt="The Black Death- A Medieval Apocalypse.jpg" srcset="/uploads/thumbnail_The_Black_Death_A_Medieval_Apocalypse_b7bde5c4f1.jpg 216w,/uploads/small_The_Black_Death_A_Medieval_Apocalypse_b7bde5c4f1.jpg 500w,/uploads/medium_The_Black_Death_A_Medieval_Apocalypse_b7bde5c4f1.jpg 750w," sizes="100vw">@The Triumph of Death by Pieter Bruegel the Elder. 1562/wikipedia.org&nbsp;Imagine the horror of witnessing loved ones succumb to agonizing symptoms—fever, swollen lymph nodes, and necrotic skin lesions. Entire communities were decimated, leaving behind ghost towns and haunted landscapes. The Black Death reshaped the course of history, triggering economic collapse, religious fervor, and profound changes in social structures.The Spanish Flu: A Global CatastropheIn the aftermath of World War I, another deadly pandemic emerged to haunt humanity—the Spanish Flu. Unlike typical influenza strains that primarily affect the young and elderly, this H1N1 virus targeted healthy adults with alarming virulence. The Spanish Flu spread rapidly across continents, facilitated by the movement of troops and civilians during the war.<img src="/uploads/the_spanish_flue_1_1f5fee6d21.jpg" alt="the-spanish-flue (1).jpg" srcset="/uploads/thumbnail_the_spanish_flue_1_1f5fee6d21.jpg 198w,/uploads/small_the_spanish_flue_1_1f5fee6d21.jpg 500w,/uploads/medium_the_spanish_flue_1_1f5fee6d21.jpg 750w,/uploads/large_the_spanish_flue_1_1f5fee6d21.jpg 1000w," sizes="100vw">@The 1918 Flu Faded in Our Collective Memory: We Might ‘Forget’ the Coronavirus, Too/scientificamerican.comThe pandemic claimed an estimated 50 to 100 million lives worldwide, far surpassing the casualties of the war itself. Hospitals were overwhelmed, and makeshift morgues overflowed with the dead. The Spanish Flu left an indelible mark on the collective psyche, underscoring the vulnerability of modern civilization in the face of microbial threats.The Plague of Justinian: An Empire in CrisisIn the sixth century, the Byzantine Empire faced a calamity of biblical proportions — the Plague of Justinian. Named after Emperor Justinian I, the plague surged with alarming speed, due to the escalation of wars against the barbarians and substantial population migration. According to historical records, the emperor was stricken by the plague in 543, but he defied the odds and ultimately recovered from the illness.<img src="/uploads/nicolas_poussin_painting_plague_ashdod_6264c34f23.jpg" alt="nicolas-poussin-painting-plague-ashdod.jpg" srcset="/uploads/thumbnail_nicolas_poussin_painting_plague_ashdod_6264c34f23.jpg 234w,/uploads/small_nicolas_poussin_painting_plague_ashdod_6264c34f23.jpg 500w,/uploads/medium_nicolas_poussin_painting_plague_ashdod_6264c34f23.jpg 750w,/uploads/large_nicolas_poussin_painting_plague_ashdod_6264c34f23.jpg 1000w," sizes="100vw">@The Plague at Ashdod by Nicolas Poussin, 1631/thecollector.comThe Plague of Justinian decimated populations across Europe and Asia, claiming an estimated 25 to 50 million lives. Entire regions were depopulated, and agricultural production plummeted, leading to widespread famine and social unrest. The Byzantine Empire, already weakened by wars and internal strife, struggled to cope with the magnitude of the crisis, hastening its decline.The Third Cholera Pandemic: A Worldwide MenaceCholera, a waterborne disease caused by the bacterium Vibrio cholerae, has haunted humanity for centuries. The third cholera pandemic, which began in the mid-19th century, stands out as one of the deadliest in recorded history. Originating in the Indian subcontinent, the pandemic spread along trade routes and shipping lanes, reaching every inhabited continent.<img src="/uploads/fedotov_cholera_2_8a4836ba15.jpg" alt="fedotov-cholera-2.jpg" srcset="/uploads/thumbnail_fedotov_cholera_2_8a4836ba15.jpg 193w,/uploads/small_fedotov_cholera_2_8a4836ba15.jpg 500w,/uploads/medium_fedotov_cholera_2_8a4836ba15.jpg 750w,/uploads/large_fedotov_cholera_2_8a4836ba15.jpg 1000w," sizes="100vw">@Pavel Fedotov’s painting shows a death from cholera in the mid-19th century, 1848/arthive.comThe relentless spread of cholera claimed millions of lives, particularly in densely populated urban centers with poor sanitation infrastructure. Victims suffered excruciating diarrhea and dehydration, succumbing to the disease within hours. The third cholera pandemic fueled fears of contagion and triggered public health interventions, laying the groundwork for modern sanitation systems and disease surveillance.The HIV/AIDS Crisis: A Modern TragedyIn the early 1980s, a mysterious illness emerged, targeting the immune system and leaving a trail of devastation in its wake—the HIV/AIDS pandemic. Initially shrouded in stigma and misinformation, HIV/AIDS spread rapidly, particularly among marginalized communities and vulnerable populations.<img src="/uploads/aids_hiv_5fe8ab4624.jpg" alt="aids-hiv.jpg" srcset="/uploads/thumbnail_aids_hiv_5fe8ab4624.jpg 206w,/uploads/small_aids_hiv_5fe8ab4624.jpg 500w,/uploads/medium_aids_hiv_5fe8ab4624.jpg 750w," sizes="100vw">@To respond to monkeypox, health officials’ playbook informed by failures of the AIDS crisis/pbs.orgThe pandemic has claimed over 36 million lives worldwide, transforming the landscape of public health and human rights. The HIV/AIDS crisis spurred global efforts to combat the epidemic, leading to groundbreaking advancements in antiretroviral therapy and prevention strategies.As we navigate the challenges posed by the COVID-19 pandemic, it's crucial to draw lessons from history's darkest chapters. The epidemics discussed above serve as stark reminders of the unpredictable nature of infectious diseases and the importance of global solidarity in combating them. While the coronavirus may seem daunting in its scale and scope, humanity has weathered far deadlier storms in the past. By learning from the mistakes and triumphs of our ancestors, we can forge a path towards a healthier and more resilient future.

#science

What do we need to know about horseshoe crabs that have saved millions of human lives?

Unveiling the Horrors: Epidemics Worse Than the Coronavirus

Tags